Why is the use of Sildenafil 200mg contraindicated with nitrates?

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Sildenafil 200mg is contraindicated with nitrate medications because both drugs significantly lower blood pressure. Nitrates, commonly prescribed for heart conditions like angina, work by dilating blood vessels, while sildenafil also relaxes blood vessels to improve blood flow. When combined, these effects can cause a dangerous drop in blood pressure, leading to dizziness, fainting, heart attack, or even stroke. Patients taking nitroglycerin, isosorbide dinitrate, or isosorbide mononitrate should avoid sildenafil and consult a doctor for alternative ED treatments. Mixing sildenafil with nitrates is a life-threatening risk and must be strictly avoided for heart health and overall safety.